BDBM476448 2-chloro-3,4-dimethylphenyl (3S)-4- [N-(2-benzyl-2-azaspiro[4.5]dec-8- yl)-6-piperidin-1-yl-D-norleucyl]-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 104

SMILES Cc1ccc(OC(=O)N2CCN([C@@H](C2)C(=O)NCc2cccs2)C(=O)[C@@H](CCCCN2CCCCC2)NC2CCC3(CCN(Cc4ccccc4)C3)CC2)c(Cl)c1C

InChI Key InChIKey=BBSWYLBBGODMRK-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476448   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM476448(2-chloro-3,4-dimethylphenyl (3S)-4- [N-(2-benzyl-2...)
Affinity DataIC50: 0.200nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent