BDBM476049 US10865208, Compound I-106::[(2R,3R,4S,5R)-5-{4-amino-3-[(3-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4- d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate
SMILES Nc1ncnc2n(nc(Sc3cccc(Cl)c3)c12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@@H]1F
InChI Key InChIKey=XIZNXSSAZSFJJR-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 476049
Affinity DataIC50: 35nMAssay Description:The total volume of the ATG7 enzymatic assay is 50 μL and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 0.01% Tween-20, 25 mM NaCl, 5 mM ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of GST-tagged ATG3 and Flag-tagged Gabarap and measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 198nMAssay Description:Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioester formation after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioester formation after 8 hrs by Western blot analysisMore data for this Ligand-Target Pair