BDBM476012 US10865208, Compound I-69::[(2R,3S,4R,5R)-5-{4-amino-3-[(3-methylphenyl)sulfanyl]-1H-pyrazolo[3,4- d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate

SMILES Cc1cccc(Sc2nn([C@@H]3O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]3O)c3ncnc(N)c23)c1

InChI Key InChIKey=YPIQMHCQPHVWIF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 476012   

TargetUbiquitin-like modifier-activating enzyme ATG7(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM476012([(2R,3S,4R,5R)-5-{4-amino-3-[(3-methylphenyl)sulfa...)
Affinity DataIC50: 20nMAssay Description:The total volume of the ATG7 enzymatic assay is 50 μL and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 0.01% Tween-20, 25 mM NaCl, 5 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetUbiquitin-like modifier-activating enzyme ATG7(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM476012([(2R,3S,4R,5R)-5-{4-amino-3-[(3-methylphenyl)sulfa...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of GST-tagged ATG3 and Flag-tagged Gabarap and measured after 2 hr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM476012([(2R,3S,4R,5R)-5-{4-amino-3-[(3-methylphenyl)sulfa...)
Affinity DataIC50: 178nMAssay Description:Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioester formation after 8 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed