BDBM475995 US10865208, Compound I-53::{(2R,3S,4R,5R)-5-[4-amino-3-(tert-butylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin- 1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate

SMILES CC(C)(C)Sc1nn([C@@H]2O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12

InChI Key InChIKey=DRTHISUFMFDTKE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475995   

TargetUbiquitin-like modifier-activating enzyme ATG7(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM475995({(2R,3S,4R,5R)-5-[4-amino-3-(tert-butylsulfanyl)-1...)
Affinity DataIC50: 35nMAssay Description:The total volume of the ATG7 enzymatic assay is 50 μL and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 0.01% Tween-20, 25 mM NaCl, 5 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent