BDBM475923 (4S)-4-[[(2S)-2-[[(2R)-2- (3-chloro-5- cyanophenoxy)-3-(3- chlorophenyl)propanoyl] amino]-2- phenylacetyl]amino]-2,2- difluoro-5-methyl-3-oxo- N-(2,2,2- trifluoroethyl)hexanamide::US10865182, Example 13

SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1cccc(Cl)c1)Oc1cc(Cl)cc(c1)C#N)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F

InChI Key InChIKey=VKUPNFSRVTWCND-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475923   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM475923((4S)-4-[[(2S)-2-[[(2R)-2- (3-chloro-5- cyanophenox...)
Affinity DataIC50: 0.293nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent