BDBM475919 (4S)-4-[[(2S)-2-[[(2R)-2- (3-chlorophenoxy)-3-(3,5- dichlorophenyl)propanoyl] amino]-2-(4- methoxyphenyl)acetyl] amino]-2,2-difluoro-5- methyl-3-oxo-N-(2,2,2- trifluoroethyl)hexanamide::US10865182, Example 9

SMILES COc1ccc(cc1)[C@H](NC(=O)[C@@H](Cc1cc(Cl)cc(Cl)c1)Oc1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F

InChI Key InChIKey=CULUMSKELKBMIF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475919   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM475919((4S)-4-[[(2S)-2-[[(2R)-2- (3-chlorophenoxy)-3-(3,5...)
Affinity DataIC50: 2.83nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
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