BDBM475917 (4S)-4-[[(2S)-2-[[(2R)-3- (3-chlorophenyl)-2-(3,5- dicyanophenoxy)propanoyl] amino]-2-(4- methoxyphenyl)acetyl] amino]-2,2-difluoro-5- methyl-3-oxo-N-(2,2,2- trifluoroethyl)hexanamide::US10865182, Example 7

SMILES COc1ccc(cc1)[C@H](NC(=O)[C@@H](Cc1cccc(Cl)c1)Oc1cc(cc(c1)C#N)C#N)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F

InChI Key InChIKey=AUOGGXBXWJKVMJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475917   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM475917((4S)-4-[[(2S)-2-[[(2R)-3- (3-chlorophenyl)-2-(3,5-...)
Affinity DataIC50: 1.09nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
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