BDBM474484 5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifluoro-phenyl)-oxazole-4- carboxylic acid amide::US10882829, Example 21::US11673870, Example 21

SMILES CS(=O)(=O)c1ccc(Nc2oc(nc2C(N)=O)-c2c(F)cc(F)cc2F)cc1

InChI Key InChIKey=PWKNMZKSSBJPFN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474484   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 68.3nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 241nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 412nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 2.18E+3nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 68.3nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 241nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 412nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474484(5-(4-Methanesulfonyl- phenylamino)-2-(2,4,6- trifl...)
Affinity DataIC50: 2.18E+3nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent