BDBM474473 Example U-3 in WO2008/139161::US10882829, Example 10::US11673870, Example 10

SMILES CNCCNC(=O)c1ccc(Nc2oc(nc2C(N)=O)-c2c(F)cccc2F)cc1

InChI Key InChIKey=AHMNDNNZRGRDKV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474473   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 20.5nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 183nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 311nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 397nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 20.5nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 183nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 311nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sareum

US Patent
LigandPNGBDBM474473(Example U-3 in WO2008/139161 | US10882829, Example...)
Affinity DataIC50: 397nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent