BDBM472735 2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((trans)-4-hydroxycyclohexyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::US10829492, Example 12

SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=GDRBSYPCEZXZEN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 472735   

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetNT-3 growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 20nMAssay Description:JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 1nMAssay Description:TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent