BDBM471604 US10822334, Compound 16

SMILES COc1cc(O[C@H]2CCNCC2(F)F)c2c(Nc3ccc(Oc4ccn5ncnc5c4)c(C)c3)ncnc2c1

InChI Key InChIKey=MGBJUGCCYZJVGR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 471604   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
TBA

US Patent
LigandPNGBDBM471604(US10822334, Compound 16)
Affinity DataIC50: 10.6nMAssay Description:HER2: The compounds' inhibition of target modulation were determined as follows: BT474 cells were sorted in 96 well plates (20000 cells/well) wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
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TargetEpidermal growth factor receptor(Human)
TBA

US Patent
LigandPNGBDBM471604(US10822334, Compound 16)
Affinity DataIC50: 3.06E+3nMAssay Description:EGFR: The compounds' inhibition of target modulation were determined as follows: NCI-H838 cells were sorted in 96 well plates (20000 cells/well) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent