BDBM468328 US10806720, Compound 1008::US11648234, Compound 1008

SMILES C[C@](O)(Cn1ccnc1)C(=O)Nc1ccc(C#N)c(Cl)c1

InChI Key InChIKey=BBWRLVHACPDSNA-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468328   

TargetAndrogen receptor(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468328(US10806720, Compound 1008 | US11648234, Compound 1...)
Affinity DataIC50: 1.86E+3nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468328(US10806720, Compound 1008 | US11648234, Compound 1...)
Affinity DataIC50: 1.86E+3nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK-293 cells harboring GRE-LUC and CMV-renilla luciferase assessed as inhibition of tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAndrogen receptor [633-919](Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468328(US10806720, Compound 1008 | US11648234, Compound 1...)
Affinity DataIC50: 1.86E+3nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetAndrogen receptor(Rat)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468328(US10806720, Compound 1008 | US11648234, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H] MIB binding to rat prostate androgen receptor LBD by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed