BDBM468101 (R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobutoxy-4- methylpyridin-3-yl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8- triazaacenaphthylene-2-carboxamide;::US10800792, Example 766::US10800792, Example 767::US10822348, Example 767

SMILES CC(C)COc1cc(C)c(cn1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCCN(C4)C(=O)C=C)c([nH]c1=O)c23

InChI Key InChIKey=IZNLYDDHDUCRJW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468101   

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468101((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuto...)
Affinity DataIC50: 6.31nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468101((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuto...)
Affinity DataIC50: 1.00E+3nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468101((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuto...)
Affinity DataIC50: 6.31nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM468101((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuto...)
Affinity DataIC50: 1.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent