BDBM46658 1,2-benzothiazol-3-one::MLS-0254244.0001::US9011882, Table 1, Compound 20::acs.jmedchem.1c00409_ST.166::cid_17520

SMILES O=c1[nH]sc2ccccc12

InChI Key InChIKey=DMSMPAJRVJJAGA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 46658   

TargetPhosphomannomutase 2(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetMannose-6-phosphate isomerase(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 1.22E+4nMAssay Description:Data Source: Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute Network...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 1.32E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
Go to US Patent

TargetCaspase-3(Human)
Tianjin University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 4.67E+4nMAssay Description:Inhibition of human recombinant caspase-3 using Ac-LDEVD-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCaspase-7(Human)
Tianjin University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 1.37E+5nMAssay Description:Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCaspase-3(Human)
Tianjin University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 4.67E+4nMAssay Description:Inhibition of recombinant human caspase-3 using Ac-LDEVD-AMC as substrate assessed as accumulation of 7-AMC incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of Parma

Curated by ChEMBL
LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 307nMAssay Description:Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM46658(MLS-0254244.0001 | cid_17520 | 1,2-benzothiazol-3-...)
Affinity DataIC50: 660nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed