BDBM466567 US10800755, Example 21::US11014905, Example 21

SMILES FC(F)(F)c1cccc(n1)C1CCN(CCNC(=O)[C@H]2C[C@@H]3CC[C@H]2O3)CC1

InChI Key InChIKey=LGQIOUYNFUYGTH-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 466567   

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataIC50: 15nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
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TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataIC50: 201nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataIC50: 2.17E+3nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:The activity of the present compound for inhibiting hERG channel was measured by whole-cell patch clamp method with auto patch clamp system, using CH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataEC50:  84nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataEC50:  65nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataKi:  15nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataKi:  201nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466567(US10800755, Example 21 | US11014905, Example 21)
Affinity DataKi:  2.17E+3nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent