BDBM466549 US10800755, Example 5::US11014905, Example 5

SMILES COCC(C)(C)C(=O)NCCN1CCC(CC1)c1cccc(C)n1

InChI Key InChIKey=HBHQINPAMGZPQL-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 466549   

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataIC50: 80nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataIC50: 170nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataIC50: 1.00E+4nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataIC50: 4.82E+4nMAssay Description:The activity of the present compound for inhibiting hERG channel was measured by whole-cell patch clamp method with auto patch clamp system, using CH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataEC50:  42nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataEC50:  55.8nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataKi:  80nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetD(4) dopamine receptor(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataKi:  170nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466549(US10800755, Example 5 | US11014905, Example 5)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent