BDBM463784 6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrrolo[2,3-c]pyridin- 4-yl)-2-phenyl-2H-1,4-::US10781209, Example 24::US11059821, Example 24

SMILES COc1cc2N(C)CC(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)c1ccccc1

InChI Key InChIKey=GCUFENZVZMDQEP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 463784   

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandPNGBDBM463784(6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrro...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandPNGBDBM463784(6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrro...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandPNGBDBM463784(6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrro...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM463784(6-methoxy-8-(6-methyl-7- oxo-6,7-dihydro-1H- pyrro...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
Go to US Patent