BDBM463430 3-amino-N-[(3R)-1-(3-chlorophenyl)pyrrolidin-3-yl]-1-({4-[(2-oxopyridin-1-::US10781181, Example 106

SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)N[C@@H]1CCN(C1)c1cccc(Cl)c1

InChI Key InChIKey=QZVBCPBEJSYHNK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 463430   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463430(3-amino-N-[(3R)-1-(3-chlorophenyl)pyrrolidin-3-yl]...)
Affinity DataIC50: 684nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463430(3-amino-N-[(3R)-1-(3-chlorophenyl)pyrrolidin-3-yl]...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463430(3-amino-N-[(3R)-1-(3-chlorophenyl)pyrrolidin-3-yl]...)
Affinity DataIC50: 684nMAssay Description:Inhibition of plasma kallikrein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed