BDBM462294 US10766894, Compound TABLE 1.11::US11203595, TABLE 1.11

SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@@H]1CC[C@H](C[C@H]1C#N)N1CCC1

InChI Key InChIKey=XWCANLMOBFDTMY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 462294   

TargetTyrosine-protein kinase JAK1(Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 240nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 1.00E+4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 120nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 2nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 240nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Novartis

US Patent
LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 1.00E+4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM462294(US10766894, Compound TABLE 1.11 | US11203595, TABL...)
Affinity DataIC50: 120nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
US Patent