BDBM461386 US10774069, Compound Rac-1::US11072585, Example 121::US11459309, Compound Ent-1::US11793797, Compound Ent-1

SMILES NCc1cc(Oc2cccc(c2)C(=O)N2C[C@H](O)[C@@H](F)C2)nc(c1)C(F)(F)F

InChI Key InChIKey=ODGXXYXJORZPHE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 461386   

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461386(US10774069, Compound Rac-1 | US11072585, Example 1...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-containing) from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461386(US10774069, Compound Rac-1 | US11072585, Example 1...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461386(US10774069, Compound Rac-1 | US11072585, Example 1...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461386(US10774069, Compound Rac-1 | US11072585, Example 1...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-containing) from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461386(US10774069, Compound Rac-1 | US11072585, Example 1...)
Affinity DataIC50: 300nMAssay Description:Table 8: LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent