BDBM460930 US10774053, Compound 43::US11352329, COMPD # 43

SMILES CC(C)(C)C[C@@]1(NC(=N)N([C@H](COC(=O)NC2(C)CC2)c2ccc(Cl)c(c2)-c2ncnn2C2CC2)C1=O)c1ccc(cc1)-c1cnn(c1)C(F)F

InChI Key InChIKey=QYKCEACKZWPLGG-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 460930   

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460930(US10774053, Compound 43 | US11352329, COMPD # 43)
Affinity DataIC50: 1.70nMAssay Description:Compounds were tested in a high-throughput 384-well assay format for their ability to inhibit the replication of HIV-1 (IIIB) in MT-4 cells. Compound...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460930(US10774053, Compound 43 | US11352329, COMPD # 43)
Affinity DataEC50:  8.18nMAssay Description:Assay protocol is identical to that described for the MT-4 antiviral assay with the following changes: Each drug is run in 2 series of quadruplicates...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGag-Pol polyprotein(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460930(US10774053, Compound 43 | US11352329, COMPD # 43)
Affinity DataIC50: 1.70nMAssay Description:Inhibitor potency against HIV protease was measured using an enzymatic assay with a fluorogenic readout. To a reaction buffer containing 100 mM ammon...More data for this Ligand-Target Pair
In DepthDetails
US Patent