BDBM458525 2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)methyl)-3-methoxybenzyl)amino)-5-methyl-N-(thiazol-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US10745392, Example 18::US11325902, Example 18

SMILES COc1ccc(F)c(CNc2cc(F)c(cc2C)S(=O)(=O)Nc2cscn2)c1CN(C)C(C)C

InChI Key InChIKey=XQWQLJLBKZZOCK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 458525   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458525(2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)m...)
Affinity DataIC50: 16nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458525(2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)m...)
Affinity DataIC50: 1.18E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458525(2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)m...)
Affinity DataIC50: 3.00E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458525(2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)m...)
Affinity DataIC50: 16nMAssay Description:The following patch voltage clamp electrophysiology studies may be performed on representative compounds of the invention using human embryonic kidne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458525(2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)m...)
Affinity DataIC50: 1.18E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458525(2-fluoro-4-((6-fluoro-2-((isopropyl(methyl)amino)m...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent