BDBM458515 2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isopropyl(methyl)amino)methyl)benzyl)amino)-N-(thiazol-4-yl)benzenesulfonamide::US10745392, Example 8::US11325902, Example 8

SMILES CC(C)Oc1ccc(F)c(CNc2cc(F)c(c(F)c2)S(=O)(=O)Nc2cscn2)c1CN(C)C(C)C

InChI Key InChIKey=OFNMIVAAJQLLTC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 458515   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458515(2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isoprop...)
Affinity DataIC50: 26nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458515(2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isoprop...)
Affinity DataIC50: 1.11E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458515(2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isoprop...)
Affinity DataIC50: 2.80E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458515(2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isoprop...)
Affinity DataIC50: 26nMAssay Description:The following patch voltage clamp electrophysiology studies may be performed on representative compounds of the invention using human embryonic kidne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458515(2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isoprop...)
Affinity DataIC50: 1.11E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458515(2,6-difluoro-4-((6-fluoro-3-isopropoxy-2-((isoprop...)
Affinity DataIC50: 2.80E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent