BDBM457866 1-(1-(2-chlorobenzyl)piperidin-4-yl)-3-(cyclopropylmethyl)-5-methyl-1H-benzo[d]imidazol-2(3H)-one::US10751335, Example 28

SMILES Cc1ccc2n(C3CCN(Cc4ccccc4Cl)CC3)c(=O)n(CC3CC3)c2c1

InChI Key InChIKey=GCDUWEOWDBFAQN-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457866   

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457866(1-(1-(2-chlorobenzyl)piperidin-4-yl)-3-(cyclopropy...)
Affinity DataEC50:  558nMAssay Description:A standard [35S]GTPγS binding assay in membranes prepared from CHO cells expressing the human MOR was performed in a concentration response mann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
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TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457866(1-(1-(2-chlorobenzyl)piperidin-4-yl)-3-(cyclopropy...)
Affinity DataEC50:  253nMAssay Description:he CisBio cAMP cell based assay kit that uses HTRF technology was utilized to assess MOR-mediated inhibition of cAMP. Assays were performed according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent