BDBM457863 5,6-dichloro-1-(1-(2-fluoro-4-methylbenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one::US10751335, Example 25

SMILES Cc1ccc(CN2CCC(CC2)n2c3cc(Cl)c(Cl)cc3[nH]c2=O)c(F)c1

InChI Key InChIKey=GJHSDFJCWFLXOK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457863   

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457863(5,6-dichloro-1-(1-(2-fluoro-4-methylbenzyl)piperid...)
Affinity DataEC50:  66nMAssay Description:A standard [35S]GTPγS binding assay in membranes prepared from CHO cells expressing the human MOR was performed in a concentration response mann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457863(5,6-dichloro-1-(1-(2-fluoro-4-methylbenzyl)piperid...)
Affinity DataEC50:  32nMAssay Description:he CisBio cAMP cell based assay kit that uses HTRF technology was utilized to assess MOR-mediated inhibition of cAMP. Assays were performed according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent