BDBM457841 1-(1-(1-(4-bromo-2-fluorophenyl)ethyl)piperidin-4-yl)-5-chloro-1H-benzo[d]imidazol-2(3H)-one::US10751335, Example 3::US10751335, Example 7

SMILES CC(N1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)c1ccc(Br)cc1F

InChI Key InChIKey=XEAFKXRBLUBNHL-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 457841   

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457841(US10751335, Example 3 | 1-(1-(1-(4-bromo-2-fluorop...)
Affinity DataEC50:  43nMAssay Description:A standard [35S]GTPγS binding assay in membranes prepared from CHO cells expressing the human MOR was performed in a concentration response mann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457841(US10751335, Example 3 | 1-(1-(1-(4-bromo-2-fluorop...)
Affinity DataEC50:  30nMAssay Description:he CisBio cAMP cell based assay kit that uses HTRF technology was utilized to assess MOR-mediated inhibition of cAMP. Assays were performed according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457841(US10751335, Example 3 | 1-(1-(1-(4-bromo-2-fluorop...)
Affinity DataEC50:  33nMAssay Description:A standard [35S]GTPγS binding assay in membranes prepared from CHO cells expressing the human MOR was performed in a concentration response mann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457841(US10751335, Example 3 | 1-(1-(1-(4-bromo-2-fluorop...)
Affinity DataEC50:  25nMAssay Description:he CisBio cAMP cell based assay kit that uses HTRF technology was utilized to assess MOR-mediated inhibition of cAMP. Assays were performed according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent