BDBM455308 US10730875, Compound 8

SMILES O[C@H]1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)cn23)C1

InChI Key InChIKey=UKBDRKYMJJIFAT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 455308   

TargetTyrosine-protein kinase JAK1(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455308(US10730875, Compound 8)
Affinity DataIC50: 750nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455308(US10730875, Compound 8)
Affinity DataIC50: 5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455308(US10730875, Compound 8)
Affinity DataIC50: 5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Jn Therapeutics

US Patent
LigandPNGBDBM455308(US10730875, Compound 8)
Affinity DataIC50: 5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN time-resolved fluorescence energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent