BDBM454894 US10730870, Example 57::US11512083, Example 57

SMILES COCCCc1ccc2C(=O)N(Cc2c1)[C@@H](C(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C

InChI Key InChIKey=DJTBXBQGAPPXCU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 454894   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454894(US10730870, Example 57 | US11512083, Example 57)
Affinity DataIC50: 717nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454894(US10730870, Example 57 | US11512083, Example 57)
Affinity DataIC50: 1.41E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454894(US10730870, Example 57 | US11512083, Example 57)
Affinity DataIC50: 717nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

TargetVHL complex(Human)
Arvinas Operations

US Patent
LigandPNGBDBM454894(US10730870, Example 57 | US11512083, Example 57)
Affinity DataIC50: 1.41E+3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent