BDBM453332 BDBM553835::US10730826, Compound 69a

SMILES COC(C)(C)C(=O)NC(CCCCN)C(=O)COC(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=DHVCXUYNDGNFST-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 453332   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 0.210nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

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TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin F(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetCathepsin Z(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 0.210nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Copy BDB DOIUS Patent

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TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Copy BDB DOIUS Patent

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TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetCathepsin F(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetCathepsin Z(Human)
Cortexyme

US Patent

LigandBDBM453332(BDBM553835 | US10730826, Compound 69a)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL