BDBM453318 BDBM553824::US10730826, Compound 18a

SMILES NCCCCC(NC(=O)C1CCCC1)C(=O)COC(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=JMYIBZJMKVECHO-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 453318   

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair

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TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

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TargetCathepsin L2(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetCathepsin F(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Copy BDB DOIUS Patent

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TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Copy BDB DOIUS Patent

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TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair

Target InfoPDB
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Copy BDB DOIUS Patent

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TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin S(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin L2(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetProcathepsin L(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

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TargetCathepsin F(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetCathepsin B(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetPro-cathepsin H(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetCathepsin K(Human)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent

LigandBDBM453318(US10730826, Compound 18a | BDBM553824)Copy SMILESCopy InChI

Affinity DataIC50: 0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL