BDBM453275 BDBM453327::US10730826, Compound 1a-non-racemic::US10730826, Compound 1a-racemic::US11325884, Compound 1

SMILES NCCCC[C@H](NC(=O)C1CCCC1)C(=O)COc1c(F)ccc(F)c1F

InChI Key InChIKey=OLIMBXKACVCIMM-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 453275   

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin L2(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin F(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 6.10E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 117nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin L2(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin F(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 6.10E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 117nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 0.0500nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 4.68E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 170nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 2.95E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin B(Human)
Cortexyme

US Patent
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 380nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent