BDBM453252 2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide::US10729691, Example 37

SMILES CN1CCc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2C1)-c1cccc(OCC(=O)NC(C)(C)C)c1

InChI Key InChIKey=JRQYXWVDIBVRHN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 453252   

LigandPNGBDBM453252(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methy...)
Affinity DataIC50: 175nMAssay Description:HT1080 cells (as well as other cell types) were plated to confluency in 96-well plates. Cells were exposed to the combination of 10 μM Oligomyci...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPutative sugar transporter(malaria parasite P. falciparum)
Kadmon

US Patent
LigandPNGBDBM453252(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methy...)
Affinity DataIC50: 175nMAssay Description:Parasite cultures were seeded in 96-well plates (1% hematocrit, 1-2% starting parasitemia, 100 μL total volume) with varying concentrations of t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM453252(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methy...)
Affinity DataIC50: 359nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM453252(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-methy...)
Affinity DataIC50: 368nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed