BDBM453039 (2R,3R,4S,5S)-2-(4-amino- 6H-7I4-pyrrolo[2,3- d]pyrimidin-7-yl)-5-((R)-7- chloro-1,3,4,5- tetrahydrobenzo[c]oxepin-1- yl)tetrahydrofuran-3,4-diol::US10711007, Example 102::US11254683, Example 102

SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCCCc2cc(Cl)ccc12

InChI Key InChIKey=XKLKWJBIKTVKMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 453039   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM453039((2R,3R,4S,5S)-2-(4-amino- 6H-7I4-pyrrolo[2,3- d]py...)
Affinity DataIC50: 6.28E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM453039((2R,3R,4S,5S)-2-(4-amino- 6H-7I4-pyrrolo[2,3- d]py...)
Affinity DataIC50: 6.28E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent