BDBM453036 (2S,3S,4R,5R)-2-((R)-6- chloro-7-methylisochroman- 1-yl)-5-(4-methyl-7H- pyrrolo[2,3-d]pyrimidin-7- yl)tetrahydrofuran-3,4-diol::US10711007, Example 99::US11214574, Ex# 99::US11254683, Example 99

SMILES Cc1cc2[C@@H](OCCc2cc1Cl)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(C)ncnc12

InChI Key InChIKey=CGYBTANMJBGPQQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 453036   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM453036((2S,3S,4R,5R)-2-((R)-6- chloro-7-methylisochroman-...)
Affinity DataIC50: 39.6nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM453036((2S,3S,4R,5R)-2-((R)-6- chloro-7-methylisochroman-...)
Affinity DataIC50: 39.6nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM453036((2S,3S,4R,5R)-2-((R)-6- chloro-7-methylisochroman-...)
Affinity DataIC50: 39.6nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent