BDBM452994 (R)-3-((1S,2R,3S,4R)-4-(4- amino-6H-7I4-pyrrolo[2,3- d]pyrimidin-7-yl)-2,3- dihydroxycyclopentyl)-6- chloroisobenzofuran-1(3H)- one::US10711007, Example 3B::US11214574, Ex# 3B::US11254683, Example 3B

SMILES Nc1ncnc2n(ccc12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)[C@H]1OC(=O)c2cc(Cl)ccc12

InChI Key InChIKey=AYZHNCVUEKECDO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 452994   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM452994((R)-3-((1S,2R,3S,4R)-4-(4- amino-6H-7I4-pyrrolo[2,...)
Affinity DataIC50: 1.02E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM452994((R)-3-((1S,2R,3S,4R)-4-(4- amino-6H-7I4-pyrrolo[2,...)
Affinity DataIC50: 1.02E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM452994((R)-3-((1S,2R,3S,4R)-4-(4- amino-6H-7I4-pyrrolo[2,...)
Affinity DataIC50: 1.02E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent