BDBM451806 US10710980, Example 38::US10947218, Example 38

SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2

InChI Key InChIKey=NSVCYZBCJCPLDO-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 451806   

TargetActivin receptor type-1 [172-499](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 7nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
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LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 1.30E+3nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1 [172-499](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 28nMAssay Description:In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples ( 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1 [172-499,R206H](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 7nMAssay Description:In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples ( 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 160nMAssay Description:In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples ( 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1 [162-503](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 1.50E+3nMAssay Description:In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples ( 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 2.60E+3nMAssay Description:In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples ( 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1 [172-499](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 7nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 1.30E+3nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1 [172-499](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 28nMAssay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1 [172-499,R206H](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 7nMAssay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 160nMAssay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1 [162-503](Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 1.50E+3nMAssay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50: 2.60E+3nMAssay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent