BDBM451725 6-(2-amino-5-(3-fluoro-5- nitrophenyl)pyridin-3-yl)-3,4- dihydroisoquinolin-1(2H)-one::US10710978, Compound I-17

SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(F)cc(c1)[N+]([O-])=O

InChI Key InChIKey=XWUYDQYLLPTFHP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451725   

TargetSerine/threonine-protein kinase 4(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451725(6-(2-amino-5-(3-fluoro-5- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: 120nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451725(6-(2-amino-5-(3-fluoro-5- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 24(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451725(6-(2-amino-5-(3-fluoro-5- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 26(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451725(6-(2-amino-5-(3-fluoro-5- nitrophenyl)pyridin-3-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent