BDBM450758 US10676467, Compound TZ 33 21

SMILES CN(CCC(O)=O)Cc1ccc(cc1F)-c1noc(n1)-c1ccc(-c2ccccc2C)c(c1)C(F)(F)F

InChI Key InChIKey=WGQKJRQXCSGORT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 450758   

TargetSphingosine 1-phosphate receptor 1(Human)
Washington University

US Patent
LigandPNGBDBM450758(US10676467, Compound TZ 33 21)
Affinity DataIC50: 3.80nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Washington University

US Patent
LigandPNGBDBM450758(US10676467, Compound TZ 33 21)
Affinity DataIC50: 1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Washington University

US Patent
LigandPNGBDBM450758(US10676467, Compound TZ 33 21)
Affinity DataIC50: 1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Washington University

US Patent
LigandPNGBDBM450758(US10676467, Compound TZ 33 21)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to recombinant human S1PR1 expressed in cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed