BDBM449878 US10703751, Example 4::trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuteriomethylamino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile

SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O

InChI Key InChIKey=ROANNSYULQYJLV-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 449878   

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449878(trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuterio...)
Affinity DataEC50:  3.46nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM449878(trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuterio...)
Affinity DataEC50:  153nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM449878(trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuterio...)
Affinity DataEC50:  2.31E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

LigandPNGBDBM449878(trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuterio...)
Affinity DataEC50:  43nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent