BDBM449876 US10703751, Example 2::US10703751, Example 3::trans-2-[4-[2-[(1S)-1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclo-hexyl]acetonitrile (Compound 2) and trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methyl-amino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile

SMILES CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O

InChI Key InChIKey=ROANNSYULQYJLV-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 449876   

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  44.4nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  1.13E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  9.82E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  466nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  3.48nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  171nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  1.70E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  32nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In DepthDetails
US Patent