BDBM448752 (4S)-3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]pyrimidin-4-yl]-4-isopropyl-oxazolidin-2-one, Isomer 1::US10696665, Example 20::US10696665, Example 21

SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2)C(CC2CC2)N2CCN(CC2)C(=O)C=C)n1

InChI Key InChIKey=BCVLRKJGVBFIKC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 448752   

LigandPNGBDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In DepthDetails
US Patent