BDBM446700 (6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapentacyclo[17.5.2.02,6.07,12.022,6] hexacosa-1(25),7,9,11,19(26),20,23- heptaen-18-one::US10688100, Compound 3

SMILES Fc1cnc2CCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1

InChI Key InChIKey=COFVTKKTPFIGHL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 446700   

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Array Biopharma

US Patent
LigandPNGBDBM446700((6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapent...)
Affinity DataIC50: 1.20nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [L2026M](Human)
Array Biopharma

US Patent
LigandPNGBDBM446700((6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapent...)
Affinity DataIC50: 9.40nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Human)
Array Biopharma

US Patent
LigandPNGBDBM446700((6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapent...)
Affinity DataIC50: 1.20nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandPNGBDBM446700((6R)-9-fluoro-13-oxa-2,11,17,21,22,25- hexaazapent...)
Affinity DataIC50: 0.300nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent