BDBM446460 (R)-1-((7-cyano-2-(3′-(7-(((S)-3-hydroxy-3-methylpyrrolidin-1-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)-3-methylpyrrolidine-3-carboxylic Acid::US10669271, Example 13::US11124511, Example 13

SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@](C)(C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@](C)(O)C3)cc2n1

InChI Key InChIKey=AJMVAOKZKQTANQ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 446460   

LigandPNGBDBM446460(US10669271, Example 13 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
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LigandPNGBDBM446460(US10669271, Example 13 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataIC50: 10nMAssay Description:U2OS/PD-L1 cells (DiscoveRx Corporation) were maintained in McCoy's 5A medium with addition of 10% FBS, 0.25 μg/ml Puromycin. After removing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
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TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446460(US10669271, Example 13 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

LigandPNGBDBM446460(US10669271, Example 13 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent