BDBM445542 2-{8-Fluoro-5-[(5-methyl-1,2-oxazol-3-yl)(oxan-4-yl)methyl]-7-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol::US10683290, Example 34::US10683290, Example 35

SMILES Cc1cc(no1)C(C1CCOCC1)n1c2cc(-c3c(C)nnn3C)c(F)cc2c2ncc(cc12)C(C)(C)O

InChI Key InChIKey=OPGYUCHNVCWIIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445542   

TargetBromodomain-containing protein 4 [1-477](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM445542(2-{8-Fluoro-5-[(5-methyl-1,2-oxazol-3-yl)(oxan-4-y...)
Affinity DataIC50: 1nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [1-477](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM445542(2-{8-Fluoro-5-[(5-methyl-1,2-oxazol-3-yl)(oxan-4-y...)
Affinity DataIC50: 1.50E+3nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent