BDBM445524 2-{7-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl]-5-[(S)-oxan-4-yl(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol::US10683290, Example 16

SMILES Cc1nnn(C)c1-c1ccc2c(c1)n([C@@H](C1CCOCC1)c1ccccc1)c1cc(cnc21)C(C)(C)O

InChI Key InChIKey=LHUPUFVIXSYKRE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445524   

TargetBromodomain-containing protein 4 [1-477](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM445524(US10683290, Example 16 | 2-{7-[4-(2H3)Methyl-1-met...)
Affinity DataIC50: 5nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
Go to US Patent

TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445524(US10683290, Example 16 | 2-{7-[4-(2H3)Methyl-1-met...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445524(US10683290, Example 16 | 2-{7-[4-(2H3)Methyl-1-met...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed