BDBM445155 (S)-N-(4-(3-Chlorophenyl)thiazol-2-yl)-1-cyano-N-ethylpyrrolidine-2-carboxamide::US10669234, Example 109::US11319287, Example 109

SMILES CCN(C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1nc(cs1)-c1cccc(Cl)c1

InChI Key InChIKey=IDGCQIKYYGMWLZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 445155   

TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM445155(US10669234, Example 109 | (S)-N-(4-(3-Chlorophenyl...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM445155(US10669234, Example 109 | (S)-N-(4-(3-Chlorophenyl...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM445155(US10669234, Example 109 | (S)-N-(4-(3-Chlorophenyl...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM445155(US10669234, Example 109 | (S)-N-(4-(3-Chlorophenyl...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent