BDBM4445 4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile::4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile::6,7-dialkoxyquinoline-3-carbonitrile deriv. 8::CHEMBL111038

SMILES COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OC

InChI Key InChIKey=CQKFTSMPIIYOBX-UHFFFAOYSA-N

Data  7 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 4445   

TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 190nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 191nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human EGFR kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataKd:  12nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4445(4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed