BDBM443338 2'-Oxo-6'-(pyrimidin-5-yl)-1',4'- dihydro-2'H-spiro[pyrrolidine-3,3'- quinoline]-1-carbonitrile::US10654853, Example 111::US11236092, Example 111

SMILES O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cncnc1

InChI Key InChIKey=IGUWCEQSRYMPRU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 443338   

TargetOTU domain-containing protein 7B(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM443338(US10654853, Example 111 | 2'-Oxo-6'-(pyrimidin-5-y...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetOTU domain-containing protein 7B(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM443338(US10654853, Example 111 | 2'-Oxo-6'-(pyrimidin-5-y...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetOTU domain-containing protein 7B(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM443338(US10654853, Example 111 | 2'-Oxo-6'-(pyrimidin-5-y...)
Affinity DataIC50: 550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent