BDBM442821 US10653688, Compound 10::US10653688, Compound 151::US10653688, Compound 62

SMILES O=C(CN1CCOCC1)Nc1cc2cc(ccc2cn1)-c1cccnc1

InChI Key InChIKey=CLBWIBGTPGZZNC-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 442821   

LigandPNGBDBM442821(US10653688, Compound 62 | US10653688, Compound 151...)
Affinity DataEC50:  9nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

LigandPNGBDBM442821(US10653688, Compound 62 | US10653688, Compound 151...)
Affinity DataEC50:  13nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM442821(US10653688, Compound 62 | US10653688, Compound 151...)
Affinity DataEC50:  525nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM442821(US10653688, Compound 62 | US10653688, Compound 151...)
Affinity DataEC50:  455nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM442821(US10653688, Compound 62 | US10653688, Compound 151...)
Affinity DataEC50:  795nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

LigandPNGBDBM442821(US10653688, Compound 62 | US10653688, Compound 151...)
Affinity DataEC50:  8nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent