BDBM439603 US10633345, Compound 227d::US10689346, Compound 227d::US11203574, Compound 227d::US11230530, Compound 227d::US11685721, Compound 227d::US11708332, Compound 227d

SMILES NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1cc(ccc1F)C(NCC1CC1)c1ccccc1)C(F)(F)F

InChI Key InChIKey=HUIANTFJQLRTEM-UHFFFAOYSA-N

Data  7 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 439603   

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-p-nitroaniline as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM439603(US10689346, Compound 227d | US10633345, Compound 2...)
Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent